Anti-Aging Night Cream with Matrixyl 3000®

Wrinkle Reducing & Skin Tightening

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Anti-Aging Night Cream with Matrixyl 3000®

  • $69/item
    Total $69 ($89)
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    Total $128 ($267)
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    Total $198 ($534)
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Free shipping within the US on orders of $79 or more

Agelyss™ Anti-Aging Night Cream is designed for night-time healing and repair. It delivers powerful and highly concentrated active ingredients directly into the skin, penetrating deeply and intensely to hydrate, rejuvenate, revitalize and nourish your face and neck. Our super formula combines 6 clinically-proven, patented and trademarked active ingredients specially formulated to improve skin texture, promote a healthy glow, enhance collagen and elastin production, activate cell renewal and repair to slow down the signs of aging and provide a protective layer against harmful environmental elements. Easy and light to apply, it absorbs quickly without feeling greasy or sticky on your face or neck to give you super plump and smooth skin. Suitable for all skin types and age groups.
Water, Palmitoyl Tripeptide-5, Spilanthes Acmella Flower Extract, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Carboxymethyl Beta-Glucan, Glycerin, Pseudoalteromonas Ferment Extract, Palmitoyl Oligopeptide, Hydrolyzed Wheat Protein, Tripeptide-1, Ergothioneine, Tripeptide-10 Citrulline, Rhododendron Ferrugineum Leaf Cell Culture Extract, Caprylic/Capric Triglyceride, Hydrolyzed Soy Protein, Palmitoyl Tetrapeptide-7, Tocopheryl Acetate (Vitamin E), Caprylyl Glycol, Cetyl Alcohol, Mineral Oil, Citrus Bergamia (Bergamot) Fruit Oil, Trideceth-6, Butylene Glycol, Glyceryl Stearate, Ethylhexylglycerin, Phenoxyethanol, Acrylamide/Sodium Acrylate Copolymer, Isomalt, Xanthan Gum, Lecithin, Sodium Acrylate/Sodium Acryloyl Dimethyl Taurate Copolymer, Sodium Benzoate, Lactic Acid, Potassium Sorbate, Carbomer, Polysorbate 20, Triethanolamine, Tetrasodium EDTA.
SUGGESTED USE: Apply directly onto the entire face and neck. For best results, apply every night before bed. Suitable for all skin types.

Benefits of this product:

  • Tightens, tones & lifts skin for instant facelift effect
  • Increases skin hydration by 95% for nourished moisture boost
  • Boosts collagen production & repairs damaged skin
  • Targeted anti-aging science to smooth fine lines & wrinkles
  • Preserves human skin stem cells’ function & aids skin renewal
  • Protects from external elements & reduces photo-aging
  • Improves facial contours by retightening dermal architecture
  • Boosts skin immunity to protect against microbial pathogens
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Sharon F.
"From the hermetically sealed pump to the way it seamlessly absorbs into my skin and fully hydrates, I adore this age defying serum. Don't settle for substitutes!"
"I don't expect miracles from a skincare product, but this one has kept my skin looking and feeling it's best as I age. People think I'm 10-15 years younger than I really am which leaves me feeling fabulous. "
"I'm highly skeptical and very cautious about most beauty products, and I have found this product to do all it says it does. I am so grateful for this serum. It's just amazing and affordable. "
Ruth L.
"This is a high-quality product which costs a fraction of the luxury brands! I've tried many expensive products over the years and this one works just as well, if not better. "
Sally M.
"Love the results and the way it makes my skin feel! I never thought I would feel so strongly about a skincare product but I am over-the-moon! "
"This serum is lit! I absolutely love how it feels after I put it on. It is way better than anything I've tried before. "
"My daughter didn't know that I started using this night cream and so I was surprised when she told me that my skin looked smoother. I can definitely see that my wrinkles have been filled in and I'm so happy someone else noticed!"
" I'm middle aged with mixed dry/normal skin and was searching for a product to keep my skin feeling dewy and youthful while using ingredients that aren't harmful. THIS PRODUCT IS THE ANSWER... I am beyond thrilled!"
Fran I.
"I have sensitive combination skin. I ordered this serum on a whim and immediately fell in love. This calms my skin and keeps it hydrated. I have actually left my house without any makeup on since using this serum - which is almost unheard of for me!"
Martha A.
"I will be looking to purchase more products from this company because I have been so pleased from my results! Waking up with refreshed skin is a true pleasure I could not have appreciated in my 20s!"
Anna W.
"This product works! I have seen the lines diminish and my skin, particularly around the mouth and eyes become more plump. I highly recommend. Great value. I’m 58 and have used lots of products in all price ranges."
Lily H.
"My skin loves this night cream. I have sensitive and acne prone skin... my skin looks more supple and girl friends have commented on my skin looking great."
"Feeling my skin tighten is confirmation that this serum is really doing its job. A small amount of this wonderful serum goes far and it is easily controllable with the pump so you only squeeze out what you need. "
"Love! Great products! Can definitely see a change in my face."
"I lust after skin and beauty care products that I can't afford with my current paycheck, which is why I am always thrilled to find products that are priced for normal people! "
Dorothy C.
"My only problem with this serum is that I have to give away all my tinted eyeglasses. For the first time in a while, I actually want people to see my face! Well done, Agelyss!"
" My skin was oily with large pores and very clogged and dull. Now it's quite vibrant with a more even tone, smaller pores and doesn't get near as greasy especially on the hot humid days. "
Dalia M.
"I am currently enamored with this age defying night cream! It revives my dull skin and gives me a burst of confidence which I didn't even realize I was lacking. "
Susie K.
"As a pharmacist, I know which ingredients to look for and how to properly read clinical studies. This is the safest and most effective nighttime cream I ever found. This has lifted my skin and has left it absolutely glowing!"
Janet M.
"When you're my age, you don't expect miracle products to revive your skin, but that is actually what I've found in this nighttime cream. I can see real changes in my face which is nothing short of remarkable."
"This Agelyss night cream makes my face feel wonderful! It's not at all greasy but instead makes my face feel "velvety smooth". After using it for a few short weeks, the wrinkles around my eye area are definitely fading."
Jaylin R.
"My mom always told me I should moisturize before bedtime but I never really understood before I used this night cream. It actually tingles when it goes on and I feel it working to keep my skin together. "
Irene Z.
"Having fully moisturized skin is a luxury I don't take for granted. My nightly ritual of using the Anti-Aging Night Cream is one I will not forgo, no matter how tired I am. I can't stop talking about it!"
Leanna P.
"My complexion changed drastically from age 40-45 and has left me trying every type of cream and serum I can get my hands on. Fortunately, the best one is also super affordable. Thanks for a superb product!"
Desiree O.
"For years I had been using my day cream at night as well. Recently I started using this night cream and have been astonished to see what a difference it makes. My skin feels intensely repaired - it's actually amazing!"
Sylvia P.
"The state of my neck was making it very difficult for me to age gracefully. However, using the nighttime cream has changed that. Upon application, I can feel my skin tightening and in the morning, I can see a difference."
Giuliana T.
"Slathering on this night cream before I go to sleep has literally changed my face. I was so depressed when I used to see my face in the mirror, but not anymore!"
Vivian L.
"As I started to go though night cream at an alarming rate, I knew I needed to find something more affordable than what I was using. This night cream is simply wonderful. It is extremely effective and doesn't cost a fortune."
Isabella B.
"When people ask me for the secret to my glowing skin, I tell them about this nighttime cream. Everyone always calls to thank me and tell me they're also hooked on it. Thank you for a truly spectacular skincare product. "
Liv S.
"This night cream is incredible! When I first noticed the signs of aging on my face, I began my nightly applications and my face responded so well. Waking up to a dewy complexion is a fantastic confidence booster. "

Anti-Aging Night Cream with Matrixyl 3000®

Wrinkle Reducing & Skin Tightening


Are You Tired Of Skin Care Products That Just Don't Work?

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There are literally hundreds of skin care manufacturers online all claiming to have the best products. But how do you know who to trust? And more importantly, how do you know which Anti-Aging Night Cream is actually going to work for you? With all of the products out there, you want to make sure you get the highest quality facial night cream available, period.

Agelyss™ was created to help you find the best possible skin care and beauty products on the market, based on extensive research. Our team, at Agelyss™, concentrates on the clinical data and actual science to make sure you get the most effective Anti-Aging Night Cream on the market, hands down.

We will guide you through our process of what to look for and what to stay away from. At the end of this page you will have a firm understanding of which Anti-Aging Night Cream is going to help you and why.

Most Skin Care Products Simply Do Not Work

Hundreds of companies and marketers have already jumped on the skin care bandwagon to try and create their own version of an Anti-Aging Night Cream. Most of them disregard the research and put together inferior products to try and cash in on the latest skin care, health and beauty trends. Most Night Creams don't work as they only contain 1 active ingredient, 2 if you're lucky. These products are watered down with about 98% inactive ingredients.

We urge you to look into any Night Cream you buy to verify what their active ingredients are. At the end of the day, you want a product that will work for you. You want ingredients with a clinical study to backup their claims. And you want a product that will do what it says it will.

There are literally hundreds of Anti-Aging Night Creams online all claiming to have the best product. But how do you know who to trust? And more importantly, how do you know which product is actually going to work for you? With all of the products out there, you want to make sure you get the highest quality product available, period.

We, at Agelyss™, have tried to make your decision simple. How? Well, we did all of the research for you. Let us show you what we discovered below...

How Do You Find An Anti-Aging Night Cream That Will Actually Work?

We understand that your end goal is to repair and rejuvenate your skin, reducing the appearance of fine lines and wrinkles to maintain a youthful appearance. Plain and simple. And you want the best Night Cream to help you do that.

You don't want to waste your time or money on something that won't work. So, how do you find an Anti-Aging Night Cream that will actually help you achieve the appearance that you're looking for?

Stick to These 3 Guidelines:

  • Make sure it contains at least 10% clinically-proven, patented and trademarked active ingredients.
    (Most only have 1-2% active ingredients and are often not clinically proven, patented or trademarked).
  • Make sure it has at least 5 clinically-proven, patented and trademarked active ingredients.
    (Most only have 1 or 2 clinically-proven, patented or trademarked ingredients, if any at all).
  • Make sure it meets all of the Agelyss™ criteria for effectiveness, safety and security. Our team put together a list of requirements to ensure you get the highest quality product.

1 It Should Contain At Least 10% Clinically-Proven Ingredients

First and foremost, check the percentage of clinically-proven, patented and trademarked ingredients.

In the majority of skin care formulas on the market today, most contain a range of ingredients - some known as active and others, inactive. The active ingredients are the ones that are going to get you the quality results that you are looking for. Many brands, including the very well known brands, use a weak concentration of active ingredients - the industry standard being around 1-2%. In addition, don't be so sure that those active ingredients are actually clinically-proven.

At Agelyss™ we understand that the active ingredients are what make the product work. That's why Agelyss™ Anti-Aging Night Cream uses a potent concentration of 10% clinically-proven active ingredients. This is unheard of in the skin care industry. Why? Because many companies are led by cost issues and not research.

Most skin care companies are driven by cost, even the well known, big ones. It's costly to include 10% clinically-proven active ingredients, which is why most products only contain 1-2%. So, be on the lookout for what percentage of clinically-proven active ingredients can be found in your products.

2 It Should Contain 5 Clinically-Proven Ingredients

Next, be sure to check the amount of clinically-proven, patented and trademarkedd ingredients.

While the percentage of active ingredients is very important, the variety is also just as important. Why? Well, each ingredient serves a different purpose, and when combined, will get you the results that you're looking for. You would need to apply 6 different creams to get the same effect as the Agelyss™ Anti-Aging Night Cream due to the different types of active ingredients it contains.

If you look at most Night Creams out there, you'll notice that they have maybe 1 or 2 active ingredients. Some are clinically-proven, others are not. While often 1 active ingredient could be very strong and effective for a certain issue, it is usually not the perfect solution as a total care, all encompassing AAnti-Aging Night Cream.

The Agelyss™ Anti-Aging Night Cream contains not 1 or 2 clinically-proven ingredients, but 6 patented and trademarked clinically-proven ingredients. Each active ingredient serves a purpose to create the perfect Anti-Aging Night Cream that will deliver top class results. No other product on the market comes close.

Trylagen® PCB

A combination of active peptides and proteins that boost the synthesis of collagen types I, III and IV to help restore and maintain youthful collagen levels and slow down degradation. Inhibits enzymatic destruction and controls collagen fibril dimension to ensure healthy, dewy and youthful skin.

Read full clinical study
Matrixyl 3000™

This anti-aging peptide combats wrinkled, sagging skin, discolorations and dryness by mimicking the body’s natural peptides, to signal to the skin it needs more collagen and elastin to retain youthful beauty

Read full clinical study
Glucare® S 2%

Revitalizes the skin's own active defense system and enhances the natural repair processes of damaged skin. Particularly suited for aging and sensitive skin, this key ingredient helps to boost the skin's natural protection system to revitalize and repair the skin resulting in healthier and less aged skin.

Read full clinical study

A patented, synthetic tripeptide that helps slow down the skin's aging process. It mimics the body’s own mechanism, simultaneously boosting collagen production and protecting against collagen degradation, actively removing wrinkles and fine lines.

Read full clinical study
Gatuline® In-Tense

A combination of active peptides and proteins to combat aging skin. Boosts collagen production and prevents collagen degradation to plump out wrinkles and smooth fine lines.

Read full clinical study
PhytoCellTec™ Alp Rose

Based on the stem cells of alpine rose leaves which contain special epigenetic factors and metabolites. Proven to preserve human skin stem cells' function and aid cell renewal.

Read full clinical study

3 Agelyss™ Criteria For Effectiveness, Safety And Security

Finally, be sure to check the product's research studies and quality standards.

For a product to contain the Agelyss™ seal of approval, it must go through a diligent research process. Every product we formulate must have the following criteria. If just one criterion is missing, that's not good enough for our standards.

Every Agelyss™ Product Must...

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  • Contain only the highest quality ingredients based on scientific research and clinical studies.
  • Contain a high percentage of patented active ingredients. Most of our products contain 10%.
  • Comply with the US Pharmacopeias quality standards for quality & purity.
  • Be third party tested to ensure safety and effectiveness.
  • Be animal and vegan friendly. Products should not be tested on animals.
  • Be hermetically sealed in an airtight vessel to ensure the integrity of ingredients.
  • Come with a protective seal to avoid contamination that might affect results.
  • Be manufactured in the USA in an FDA registered laboratory that is also cGMP certified.
  • Provide a confident money back guarantee if you don’t see the results you are looking for.

If you're looking for the highest quality skin care products available, turn to Agelyss™ first instead of wasting your time on inferior products. Agelyss™ is the best choice for quality and comes with a risk free 365-Day 100% Money Back Guarantee.

Deep Tissue

10% Active


Paraben Free

Herbal Blend




Anti-Aging &




What We're Not

When you buy at Agelyss™, you can feel confident that you are getting the highest quality premium product available, hands down. We don't cut any corners or sacrifice quality in any way.

  • We Don't Hide Behind Our Website or Our Labels.
  • Unlike many companies, Agelyss™ keeps everything very transparent. We explain in detail the research we carried out and why our formulas are created in the way that they are. We do not hide behind our labels or website. You can see the entire label of every product with the Agelyss™ seal on it.
  • No False Claims or Misleading Facts.
  • Agelyss™ never uses false claims and does not misrepresent the facts. We'll tell you what's available, what's working and why. We only quote from actual clinical studies. We'll tell you the facts behind the research and let you decide.
  • No Automatic Shipping or Auto-Billing.
  • You can trust any order purchased from Agelyss™. We will never bill your credit card without your knowledge. We will never put you on an auto-ship program. You will be billed only when you place your order and that's it.
  • We Won't Leave You High and Dry.
  • Not only do we welcome you in and encourage you to read through our research and information, we invite and welcome any questions you may have. You can email or call us at any time. We are here to help you and to provide you with a superior product that helps achieve your personal skin care goals.

Agelyss™ was created to make it easier for consumers to find high quality skin care and beauty products that they can trust at the best possible prices.

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Our Risk Free 365-Day Money Back Guarantee

If any Anti-Aging Night Cream is going to work for you, this is it.

We are so confident that this product is going to work that we offer a full one year guarantee. With a 365-day money back guarantee, you can be sure that each Agelyss™ product is the most effective and safest option available.

If you're serious about the health of your skin and stopping the signs of aging, then you should try a product that is serious about helping you achieve your goals. We did extensive research to ensure that we found the best Anti-Aging Night Cream on the market and are so confident that it's going to work for you, that we're offering you a full year to try it out.

Agelyss™ Is Re-Defining The Science Of Skin Care

We are experts in skin care. Period. We have spent years researching and developing a range of products that make the difference you are looking for. Agelyss™ is well-renowned for delivering revolutionary new products that stand head and shoulders above its peers by utilizing scientific data and research to provide first class skin care formulas. Agelyss™ is the #1 choice of skin care professionals and beauty experts all over the world.

Our brand ethos is reflected in every product that we create - innovation, efficacy and quality - form the basis of every formula that deserves our brand name. Agelyss™ combines key active, patented and trademarked ingredients with herbal botanicals that are on the cutting edge of scientific technology to achieve unparalleled results. Every step of the way, our customers needs are at the center of everything we do and the reason that drives our commitment to quality.

The expert research and formulation team at Agelyss™ work tirelessly to ensure that we remain the market leaders in re-defining skin care technology. And it shows! Our products are lush, creamy, easy to apply and smell divine. We know that you will enjoy using our products and will be thrilled with the results. So, if you are looking for innovative skin care products that are formulated to the highest standards to enhance your skin’s natural beauty and slow down the signs of aging, then you have found the best resource possible for achieving beautiful looking skin - effortlessly. We promise you - skin care never looked so good!


Rectifies and slows down aging skin by synthesizing abundant, youthful collagen for the ultimate skin repair.

All Skin Types

Formulated to restore pH balance for all skin types. Utilizing key ingredients to reduce irritation, redness or sensitivity.

Deep Dermal Repair

Active ingredients work to penetrate deep into both the dermis and the epidermis to boost moisture and repair damaged skin.

Rehydration Boost

Our revolutionary formulas provide an external hydrating boost of over 85% to smooth fine lines and improve skin texture.

Total Skin Care

Developed to provide instant results for eyes, face, neck, lashes and lips. Administers a 24-HR toning and firming boost.

Skin Protection

Offers protection from external elements and free radical damage to maintain top skin health and prevent future damage.

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8 Things To Watch Out For When Buying An Anti-Aging Night Cream

  1. Avoid Products With A Low Percentage Of Active Ingredients. - An effective, superior quality skin care product will contain a high percentage of trademarked, patented, clinically-proven ingredients, meaning that they have been tested and shown to be effective. All Agelyss™ products contain up to 10% active ingredients, which are trademarked, patented and backed by clinical research.
  2. Avoid Products With Too Few Active Ingredients. - A quality product will contain multiple clinically-proven ingredients to work on a specific area and issue. Products that contain few active ingredients may be less effective on the whole and may require the use of multiple products for the same issue.
  3. Avoid Products With No Research To Back Up Their Claims. - A good product will contain ingredients backed by clinical studies to help you better understand the results you can expect to experience. Authentic manufacturers will ensure that this information is freely accessible. Check our clinical studies page to read more about the patented and trademarked ingredients that we include within our products.
  4. Avoid Unhelpful, Dangerous Or Weak Blends. - If you’re looking for a high quality skin care product, make sure there are no added ingredients that might lower the quality. Avoid products that contain synthetic fragrances, parabens, hormones and phthalates that may cause long-term damage or dryness.
  5. Avoid Automatic Rebilling And Free Trial Offers. - Many companies often offer free trials to hook you in. However, once you buy, it is very difficult to cancel with many companies automatically billing your credit card monthly. Make sure you read the fine print and know exactly what you're paying for.
  6. Avoid Products Tested On Animals. - The truth is, that in today's scientifically advanced world, there is no need to test on animals anymore and many companies have boycotted this approach. Skin care manufacturers do not need to abuse or torture animals in order to test the effectiveness of key ingredients. All Agelyss™ products are animal and vegan friendly.
  7. Look Out For False Claims And Unsupported Facts. - Be cautious of products that claim to be the best and don't show you the facts behind their statements or use fake celebrity endorsements.
  8. Check The Seal. - Make sure that the product is hygienically sealed and comes in a hermetically sealed airtight container. This is essential to protect it from harmful external elements, as well as, to ensure the stability and freshness of the ingredients to optimize effectiveness.

Why Does Agelyss™ Have The #1 Anti-Aging Night Cream?

  • Agelyss™ was created to meet the demands of consumers wanting the highest quality cosmeceuticals at a reasonable price with verified research, science and the latest biotechnology to ensure effectiveness and safety.
  • Agelyss™ analyzes the clinical studies to determine the amount of each ingredient that will be most effective. We track down where the highest quality ingredients can be found. We review the CofA’s (Certificate of Analysis) of every product. We make sure there are no contaminants in the product that might hinder results.
  • Agelyss™ innovative skin care treatments are designed to minimize the appearance of premature aging skin, skin damage, hyperpigmentation, sun damage and are available through our online website or via Amazon.
  • Agelyss™ products come with a confident one year money back guarantee if you are not completely happy with the results that you experience. Read more below.

Risk Free - 365-Day - 100% Money Back Guarantee

Risk Free, 365 Day, 100% Money Back Guarantee

In Conclusion - Agelyss™ Anti-Aging Night Cream Exceeds Industry Standards On Multiple Fronts

Agelyss™ Anti-Aging Night Cream meets all of the criteria listed above. It’s the highest quality Night Cream of its kind available on the market and, it works. Agelyss™ products are formulated using an unparallelled strength of active ingredients - 10% active ingredients (similar products only contain 2%) PLUS, they contain at least 5 proven ingredients that are patented, trademarked and backed by clinical studies. Agelyss™ creams and serums not only meet all of the criteria of a top quality, effective skin care product - they exceed them!

Key Criteria That Agelyss™ Night Cream Meets:

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  1. Exceeds all of the strict criteria of a top quality skin/beauty care product.
  2. Contains 10% active ingredients (not 2% as in most similar products).
  3. Contains 5 active clinically-proven, patented, trademarked ingredients.
  4. Does not contain artificial fragrances, hormones, phthalates or parabens.
  5. Third-party tested and contains no contaminants that might hinder results.
  6. Is not tested on animals and is vegan friendly.
  7. Comes in a hermetically sealed container for optimum freshness and stability.
  8. Comes with a risk free 365-Day 100% Money Back Guarantee.

Which Anti-Aging Night Cream Should You Buy?

For deeply penetrating moisture repair, long-term age defying benefits and beautiful, moist, luminous looking skin, Agelyss™ Anti-Aging Night Cream is the answer. This advanced night cream meets all of the above criteria (and more) and is guaranteed to work - or your money back! Why take chances when it comes to the health of your skin? You deserve the best, so choose the best.